Egypt will keep pushing for Gaza peace, aid: PM    EGX ends week in green on Wednesday, July 23    Kibing Group plans $685m solar glass plant in Egypt's Sokhna – SCZONE chair    Remittances from Egyptians abroad surge 70% YoY in July–May: CBE    Sudan's ambassador to Egypt holds reconstruction talks on with Arab League    Egypt's current account gap narrows, but overall BoP records deficit    Egypt hosts international neurosurgery conference to drive medical innovation    Egypt, India discuss expanding industrial, investment partnerships    World Bank proposes Egypt join new global health initiative    Egypt's EDA discusses Johnson & Johnson's plans to expand investment in local pharmaceutical sector    I won't trade my identity to please market: Douzi    Egypt welcomes 25-nation statement urging end to Gaza war    Egypt, Senegal sign pharma MoU to unify regulatory standards    Famine kills more Gaza children as Israel tightens siege amid global outrage    Kuwait's Crown Prince, Egyptian minister discuss strengthening cooperation    Egyptian Drug Authority discusses plans for joint pharmaceutical plant in Zambia    Egypt's FM seeks deeper economic, security ties on five-nation West Africa tour    Two militants killed in foiled plot to revive 'Hasm' operations: Interior ministry    Egypt, Somalia discuss closer environmental cooperation    Egypt foils terrorist plot, kills two militants linked to Hasm group    Giza Pyramids' interior lighting updated with new LED system    Egypt's EHA, Huawei discuss enhanced digital health    Foreign, housing ministers discuss Egypt's role in African development push    Korea Culture Week in Egypt to blend K-Pop with traditional arts    Egypt reveals heritage e-training portal    Three ancient rock-cut tombs discovered in Aswan    Sisi launches new support initiative for families of war, terrorism victims    Egypt expands e-ticketing to 110 heritage sites, adds self-service kiosks at Saqqara    Egypt's Irrigation Minister urges scientific cooperation to tackle water scarcity    Palm Hills Squash Open debuts with 48 international stars, $250,000 prize pool    Egypt's Democratic Generation Party Evaluates 84 Candidates Ahead of Parliamentary Vote    On Sport to broadcast Pan Arab Golf Championship for Juniors and Ladies in Egypt    Golf Festival in Cairo to mark Arab Golf Federation's 50th anniversary    Germany among EU's priciest labour markets – official data    Paris Olympic gold '24 medals hit record value    A minute of silence for Egyptian sports    Russia says it's in sync with US, China, Pakistan on Taliban    It's a bit frustrating to draw at home: Real Madrid keeper after Villarreal game    Shoukry reviews with Guterres Egypt's efforts to achieve SDGs, promote human rights    Sudan says countries must cooperate on vaccines    Johnson & Johnson: Second shot boosts antibodies and protection against COVID-19    Egypt to tax bloggers, YouTubers    Egypt's FM asserts importance of stability in Libya, holding elections as scheduled    We mustn't lose touch: Muller after Bayern win in Bundesliga    Egypt records 36 new deaths from Covid-19, highest since mid June    Egypt sells $3 bln US-dollar dominated eurobonds    Gamal Hanafy's ceramic exhibition at Gezira Arts Centre is a must go    Italian Institute Director Davide Scalmani presents activities of the Cairo Institute for ITALIANA.IT platform    







Thank you for reporting!
This image will be automatically disabled when it gets reported by several people.



Breakthrough treatment from Novartis sparks new hope for HR+/HER2- advanced breast cancer patients
Published in Daily News Egypt on 02 - 10 - 2021

Novartis Pharma (Novartis Egypt), announced the launch of the newly approved treatment for PIK3CA-mutated HR+ve Advanced Breast Cancer. The FDA approval of Alpelisib is based on the genomic profile of cancer, assessing a patient's response to treatment by testing biomarkers of PIK3CA mutations and developing a treatment plan accordingly. Alpelisib is a major breakthrough in the treatment of advanced metastatic breast cancer, offering a new hope to improve the quality of life for Egyptian patients.
"Breast cancer is the most common form of cancer among Egyptian women, affecting up to 34% of women in the country. Approximately 20% of these breast cancer cases progress to the metastatic stage8. Metastatic breast cancer, or Phase IV breast cancer, is breast cancer that has spread beyond the breast to other parts of the body (such as the lungs, liver, bones or brain)9" said Prof. Hamdy Abdelazim of Clinical Oncology, Faculty of Medicine, Cairo University.
"Under the umbrella of the Egyptian Presidential Women's Health Initiative, the Ministry of Health has introduced new treatment protocols for advanced breast cancer, making the best-in-class and most innovative medications available throughout Egypt. This is a transformative milestone in the treatment of advanced breast cancer especially over the past two years, and an old dream that has come true" he added.
"In our pursuit of transformative treatments, we strive to intervene earlier in chronic illnesses and find ways to dramatically improve quality of life. For over 30 years, addressing advanced breast cancer has been a priority for Novartis; while focusing on science and with a great collaborative spirit and passion aiming for transforming patient care. In addition to that, we own the largest number of breast cancer compounds in development in the industry, including the discovery of new therapies and combinations for HR+ advanced breast cancer – the most common cancer in Egypt," explained Dr Sherif Amin, General Manager for Novartis Oncology Egypt, Morocco and Tunisia."
"With minimal adverse reactions, the targeted therapies are by far more effective than conventional cancer therapies, as this new generation of innovative therapies specifically targets cancer cells with genetic mutations. PIK3CA mutations are the most prevalent genetic mutations in metastatic breast cancer, affecting 40% of the total breast cancer's population4,5. These mutations impact tumour growth, the resistance to endocrine-based therapies, and the overall deterioration of a patient's general condition 10,11. Alpelisib is the first treatment to target PIK3CA mutations while eliminating resistance to endocrine-based therapies for patients with HR+ metastatic breast cancer 6,7" Professor of Oncology, Director of the Kasr Al-Ainy Center for Oncology and President of the Egyptian Association for Supporting Cancer Patients "CanSurvive", Mohsen Mokhtar, explained.
"Significant work has been done to explore treatments that target PIK3CA mutations and there is now a consensus amongst the scientific community that targeting this mutation may hold the key to halting the growth of metastatic breast cancer," said Ibtessam Saad Eldin, Professor of Oncology, Faculty of Medicine, Kasr Al-Aini, Cairo University.
"FDA approval of the new treatment was based on phase III results of the clinical study SOLAR-1, which highlighted the potential for Alpelisib – in combination with fulvestrant – to nearly double Progression-Free Survival (PFS) compared to fulvestrant alone, for patients with advanced HR+/HER2- breast cancer with PIK3CA mutations. The Trial also demonstrated that the addition of Alpelisib demonstrated an additional 8 months of overall survival compared to Fulvestrant alone. For women with metastatic breast cancer that has spread to the lung and liver specifically, the study showed up to an additional 14 months of overall survival 6,12,13. These results show that this approach is expected to offer new treatment alternatives and new hope for a longer life for patients, whose tumour has shown resistance to endocrine-treatments and a mutation in the PIK3CA gene," said Prof. Dejan Juric, Oncology Specialist at Massachusetts General Hospital.
"The ultimate objective of all types of advanced cancer treatments is to slow down disease progression and help manage it effectively while enabling patients to enjoy their regular daily life for the longest time possible. In recent years, the overall survival has increased significantly, giving women with advanced breast cancer new hope, particularly patients with PIK3CA mutations, who can now achieve more of their dreams. Women with breast cancer are mothers, wives, sisters, and working women. The new treatment gives them real hope in the possibility of finding an innovative solution, which would improve their quality of life and enable them to spend a longer time with their loved ones, instead of undergoing the intolerable sufferings of chemotherapy" said Dr Hisham Elghazaly, Professor of Oncology, Faculty of Medicine, Ain Shams University, and Head of the Ain Shams Medicine Research Center.


Clic here to read the story from its source.