Real Madrid are set to lose defender Pepe for the rest of the season after the Portuguese damaged the anterior cruciate ligament. "The player will be operated on shortly and the estimated time out of action is six months," Real said on their official website. Pepe was stretchered off Real's 3-2 Primera Liga win at Valencia on Saturday after landing awkwardly on his right knee. The 26-year-old center-half is now doubtful for the 2010 World Cup finals in South Africa on June 11th.