Gold falls back    Inflation at new lows    Egypt the gateway to Africa    Erdogan goes to Washington    Why does Iran hate Iraq's uprising?    Nigeria beat Zambia 3-1 to make up for opening loss in U23 AFCON    Egypt's vision for combating terrorism    Hero doctor sleep    Kemit    Don't missmusicianShahira Kamal's first solo exhibition at Arcade gallery    Don't miss the Italian Cultural Institute's workshop "Suez Canal: An Italian History"    Breaking the deadlock on the GERD    Egypt's Al-Azhar set to hold conference on reforming religious thought in Jan    Egypt MPs meet with EU diplomats in Cairo to discuss human rights criticisms    Egypt's Sisi, Russia's defence minister discuss regional crises    Israel targets Damascus home of Islamic Jihad official, group says    Iraq expresses regret at protester deaths, defends handling of unrest    Manchester City don't need to sign another defender: Kompany    'We figured things out', says England's Sterling after Gomez clash    National economic summit to take place in Egypt Tuesday    Uber: Egypt one of the most important markets in MENA    Egypt releases FY2021 budget's preliminary statement – minister    Hong Kong spirals into rare working-hour violence as police shoot protester    Egypt's parliamentary affairs minister heads to Geneva for UNHRC meetings    10 tips to have your 30s starting a lifelong success    Nike to investigate its Oregon Project following Mary Cain's NYT op-ed    ‘Shining' sequel ‘Doctor Sleep' targets $25 mln opening, has Stephen King's blessing    Sisi: Egypt believes in comprehensive approach to human rights    UK University of Hertfordshire to open campus in Egypt new capital    Egypt's bourse, banks to close Sunday to mark Prophet Muhammad's birth    Egypt rejects politicised reports on human rights conditions – parliament    Egypt to vote on 3-month extension of state of emergency Monday    Jurgen Klopp gives injury update on Egypt's Mohamed Salah    Al Pacino says follows this mantra on every acting job    Remembering Mustafa Mahmoud, philosopher of his time    Egypt's Ahly Ramadan Sobhi on Serie A clubs' radar: agent    Court sentences six to death, 41 to lifetime imprisonment violence related case    Trump says he would release Mideast peace plan after Israeli elections    ACWA Power compares 3 bids to supply production units for Luxor power station    What do you know about gold alloying?    NBE announces EGP 2.5m prizes for handball youth teams for their world achievements    Jennifer Lopez evokes Egyptian outrage post her North Coast performance    Al-Sisi honours Egypt's scholars on Science Day    IS claims responsibility for suicide bombing killing 63 in Afghan wedding    Political parties gear up for parliamentary, senate, local elections    Unprecedented Glory: Egypt win Men's U-19 World Handball Championship    12th National Egyptian Theatre Festival fuel up public theatre art scene    Ministry of Environment has a plan for "black clouds season"    







Thank you for reporting!
This image will be automatically disabled when it gets reported by several people.





Scientists find how deadly malaria parasite jumped from gorillas to humans
Published in Ahram Online on 16 - 10 - 2019

Scientists who resurrected a 50,000-year-old gene sequence have analyzed it to figure out how the world's deadliest malaria parasite jumped from gorillas to humans - giving insight into the origins of one of human history's biggest killers.
The researchers said their work also deepens understanding of a process known as zoonosis - when a pathogen that can infect animals acquires genetic changes enabling it to infect humans - as has been the case with diseases such as flu and Ebola.
In the case of the most deadly form of the malaria parasite, Plasmodium falciparum, this analysis found that it gained its ability to infect human blood cells from a section of DNA that had transferred from a gorilla parasite.
By analyzing the crucial DNA sequence, the researchers found it included a gene that produces a protein called RH5 which binds to a protein receptor in human red blood cells.
“The fact that this ancestral RH5 protein was able to bind to red blood cell receptor(s) ... from both humans and gorillas immediately provided a molecular explanation for how P. falciparum evolved to infect humans,” said Francis Galaway, who co-led the research team from Britain's Wellcome Sanger Institute and France's Montpelier University.
Malaria is spread by mosquitoes and infects around 216 million people a year worldwide, according to World Health Organization (WHO) data. The disease kills more than 400,000 people a year, the vast majority of them babies and children in the poorest parts of Africa.
“In the history of mankind, it's been estimated that malaria has been responsible for more human deaths than any other disease,” said Gavin Wright, who co-led the work.
“So it is both important and fascinating to understand the molecular pathways that enabled this deadly parasite to infect humans.”


Clic here to read the story from its source.